The first federal vaccine push in the U.S. was the Act to Encourage Vaccination of 1813 – signed by President James Madison, which required free distribution of smallpox vaccine – according to historical accounts. The measure followed lobbying by James Smith, a physician known as the “Jenner of America,” who was appointed federal vaccine agent under the law.
Congress repealed the act in 1822 after safety failures and complaints of profiteering and corruption, the same accounts state. The repeal marked the first federal retreat from vaccine regulation in the nation’s history. The episode set a template that historians and critics say has repeated for more than two centuries: government promotion of vaccination, followed by documented safety failures and followed by public backlash.
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