A study from the University of Bristol has found that regular aerobic exercise reshapes the nerves that control the heart in a side-specific manner. The findings, published in Autonomic Neuroscience on July 13, 2026, reveal that exercise rewires the heart’s nerve network asymmetrically between the left and right sides of the body.
According to the researchers, the discovery could pave the way for more precise treatments for common heart conditions such as arrhythmias, angina, and stress-induced ‘broken-heart’ syndrome. Exercise has previously been shown to trigger the release of brain-derived proteins [2] and improve white matter structure in the brain [1], but its effect on the heart’s nerve network represents a new frontier in cardiovascular research.
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