The guts of civilization: Why modern food is reprogramming your microbiome to recycle estrogen
New research shows that people in industrialized societies harbor gut microbes that are seven times more effective at reactivating estrogen and returning it to the bloodstream than those in hunter-gatherer or rural farming communities.
The estrobolome refers to gut microbes that possess an enzyme capable of reversing the liver’s deactivation of estrogen, recycling the hormone instead of excreting it. This recycling capacity is directly linked to the modern diet and lifestyle.
Formula-fed infants have nearly three times the estrogen-recycling capacity of breastfed babies, with up to eleven times greater estrobolome diversity, suggesting early-life nutrition sets the stage for lifelong hormonal imbalance.
The perpetual recycling of estrogen actively suppresses testosterone, linking the phenomenon to rising obesity, metabolic syndrome, endometriosis, cancer and a societal “crisis of masculinity” characterized by reduced drive and increased risk aversion.
A diet low in fiber forces gut microbes to feed on conjugated estrogen, reactivating it. This is worsened by endocrine-disrupting chemicals in plastics and pesticides and chronic stress, creating a perfect storm for biochemical feminization.
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