A study published in the journal Cell by researchers at the University of California, San Francisco, has identified a direct biological pathway linking exercise to brain health, according to the study. The research, conducted at the UCSF Bakar Aging Research Institute, found that physical activity prompts the liver to release an enzyme called GPLD1, which travels through the bloodstream to the brain and repairs age-related damage to the blood-brain barrier, the study stated.
The findings describe a liver-to-brain signaling mechanism that partly explains how exercise protects cognitive function, researchers said. According to the study, GPLD1 removes a protein called TNAP that accumulates on blood-brain barrier cells over time, restoring the barrier’s protective function. The research adds to a growing body of evidence on exercise and brain health while identifying a specific molecular pathway connecting the two organs.
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