Researchers have found that stress may worsen arthritis, mainly through a pathway between brown fat and the interleukin-6 (IL-6) protein.
Scientists have long suspected a link between stress and arthritis flare-ups, but the biological mechanism connecting the two had remained unclear, according to an article published by mindbodygreen [3]. The experiments involved mice with arthritis that had gone into a remission-like state before being exposed to restraint stress, the study stated [1][2]. When researchers blocked part of the stress-response pathway, arthritis flares became significantly less severe, according to the findings [3][2].
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