Research published in Nature Communications on May 3, 2026, by APC Microbiome Ireland at University College Cork found that both caffeinated and decaffeinated coffee reshape the gut microbiome in ways linked to improved mood and reduced stress, according to the study. The findings, supported by the Institute for Scientific Information on Coffee, indicate that coffee acts through multiple pathways beyond caffeine, including polyphenols and other compounds. [1] [2]
Lead researcher Dr. John Cryan, principal investigator at APC Microbiome Ireland, noted that the findings suggest coffee’s benefits extend beyond caffeine. According to the study, changes in gut microbes were associated with better mood and lower stress, while decaffeinated coffee was linked to improvements in learning and memory and caffeinated coffee to reduced anxiety and better attention. [1]
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