KLF4 protein loss in blood-brain barrier cells accelerates brain aging and cognitive decline.
Researchers found that declining KLF4 triggers blood-brain barrier breakdown, inflammation, and memory loss in mice.
Endothelial cells losing KLF4 led to early brain damage, leaking vessels, and impaired blood flow.
Vascular health is linked to 15 to 30 percent of dementia cases, with KLF4 as a key mechanism.
Until KLF4 drugs exist, exercise, sleep, and a plant-rich diet already protect brain blood vessels.
A protein most people have never heard of may determine how quickly the brain declines with age. Researchers at University Hospitals, Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center say they’ve found it: KLF4, a molecule produced by the cells lining the brain’s blood vessels.
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