A review published Dec. 11, 2025 in the journal Genes and Diseases examined links between excess weight and biological aging. Authors Rui Zhang, Linlin Liu, Xiaoman Shi, and Yanming Ren, from Sichuan University and Chongqing Medical University, reported overlapping processes involving inflammation, telomere shortening, and DNA damage, according to the paper “Obesity accelerates aging: Mechanisms and therapeutic implications.”
The review cited Canadian data indicating that about a quarter of adults are overweight or obese based on body mass index, a figure that climbs with age. According to the authors, obesity may be associated with accelerated biological aging, though precise molecular links remain unconfirmed. Earlier work has identified an inverse relationship between adiposity and telomere length, according to “AIR Vol II” by Nun Amen-Ra [1]. Chronic low-grade inflammation, called “inflammaging” in a report by ANH International, is associated with telomere shortening and impaired cellular cleanup [2].
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