A Vanderbilt clinical trial found that magnesium supplements boost beneficial gut bacteria that produce vitamin D and may protect against colorectal cancer.
The study revealed magnesium increases Carnobacterium maltaromaticum and Faecalibacterium prausnitzii, which work together to synthesize vitamin D in the gut and inhibit cancer development.
Protective effects were strongest in female participants, possibly due to estrogen’s role in cellular magnesium uptake.
The research identifies a fourth pathway for vitamin D production, where gut bacteria can synthesize vitamin D locally when supported by adequate magnesium.
Benefits were strongest in individuals with the TRPM7 gene variant that affects magnesium regulation, with reduced polyp risk in those with inadequate TRPM7 function.
A groundbreaking clinical trial from Vanderbilt University Medical Center has revealed that magnesium supplements can boost beneficial gut bacteria that produce vitamin D and may help protect against colorectal cancer. The study, published in The American Journal of Clinical Nutrition, comes at a time when colorectal cancer rates are climbing, particularly among younger adults.
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