Coffee compounds activate cellular anti-aging receptor, Texas A&M researchers find
Texas A&M scientists discovered coffee compounds activate a cellular receptor called NR4A1 that protects against stress and inflammation.
The receptor, tied to aging and disease, responded most strongly to plant-based compounds like caffeic acid, not caffeine.
When researchers removed NR4A1 from cells, coffee’s protective effects disappeared entirely.
Decaffeinated coffee may offer similar benefits since protective compounds are plant-based, not caffeine-dependent.
The findings provide a biological mechanism explaining why coffee drinkers tend to live longer with less chronic disease.
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