Vitamin D supplementation lowers a major marker of chronic inflammation in postmenopausal women
A new meta-analysis clarifies that vitamin D supplementation significantly reduces the inflammatory marker C-reactive protein (CRP) in postmenopausal women who are deficient, resolving previous contradictory research.
The anti-inflammatory benefit is most pronounced with a daily dose of at least 1,000 IU of vitamin D3 for a minimum of three months, offering a targeted strategy for a group at increased risk for chronic, age-related diseases.
This finding explains why past large-scale trials showed mixed results: the greatest protective impact comes from correcting a deficiency, with benefits plateauing once sufficient levels are reached.
Beyond bone health, the research reinforces vitamin D’s broader role, linking deficiency to higher risks of conditions like hypertension, diabetes, certain cancers and multiple sclerosis.
The practical recommendation is for at-risk individuals, particularly postmenopausal women, to get tested and if deficient, supplement under medical guidance as a direct, low-cost method to lower systemic inflammation and associated disease risk.
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