Little-known compound in aged garlic could be key to fighting age-related muscle decline
S-1-propenyl-L-cysteine in aged garlic extract activates a previously unknown fat-to-brain-to-muscle pathway for muscle protection.
This compound improved muscle strength, grip strength, and frailty scores in aged mice without increasing muscle size.
A small human trial showed the same biological signal after a single dose of 25 milligrams of S1PC.
The pathway stimulates NAD+ production by targeting the hypothalamus through eNAMPT protein secreted from fat tissue.
Further research is needed to confirm long-term functional gains in aging adults from this compound.
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