Dopamine Deficiency in Entorhinal Cortex Identified as Primary Driver of Memory Impairment in Alzheimer’s Disease
A study published in Nature Neuroscience on April 23, 2026, identifies a link between dopamine levels in the entorhinal cortex and memory impairment in Alzheimer’s disease. Researchers at the University of California, Irvine found that dopamine in this brain region was reduced to less than one-fifth of normal levels in a mouse model of Alzheimer’s. Restoring dopamine through levodopa improved memory and normalized neural activity, according to the report [1].
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