A two-year clinical trial has found that healthy adults who reduced their calorie intake by an average of 12% improved their overall diet quality and lowered markers of dietary inflammation without developing nutrient deficiencies.
The findings come from the CALERIE 2 trial (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy), which enrolled 218 healthy adults without obesity and provided extensive nutritional education to the calorie-restriction group, according to a study published in the American Journal of Clinical Nutrition [1].
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